The choice of excipients and optimization of the composition of orally disintegrating tablets based on paracetamol and N-acetyl-D-glucosamine

Aim. The choice of the qualitative and quantitative composition excipients to provide required mechanical strength disintegration time when developing a pharmaceutical in form orally disintegrating tablets (ODT) based on paracetamol N-acetyl-D-glucosamine. Materials methods. study object was pharmaceutically accepted used development solid dosage forms. To conduct statistical analysis experimental data, Minitab® 19.1.1 software used. Results discussion. (povidone different brands, copovidone, crospovidone croscarmellose) ODT were considered, it determined that copovidone type A showed most optimal quality indicators composition. It found particle sizeof route its introduction affected rate aqueous medium. Using method mathematical prediction content confirmation ofthe mixture selected create determined. Conclusions. Excipients have been exhibiting best compositions found. Both influence size crospovidone, administration their due prediction.